Author

Srinivas R. Viswanathan

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Ananthan SadagopaniD· 2 shared Jiao LiiD· 2 shared Shatha AbuHammadiD· 2 shared Abhishek A. ChakrabortyiD· 1 shared Autumn Hall· 1 shared Belinda B. WillardiD· 1 shared Bingchen LiiD· 1 shared Craig A. Strathdee· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Ananthan SadagopanORCID

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3 papers

Recent·Most cited

BCL-XL Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers

Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan, Xingping Qin, Kylee Madison, Autumn Hall, Belinda B. Willard, Sakari Vanharanta, Kristopher A. Sarosiek, Srinivas R. Viswanathan, Abhishek A. Chakraborty

The paper identifies BCL-XL dependence as a common vulnerability in various kidney cancer subtypes and develops a model to predict it using biomarkers like AMPK activation.

Cell Death and Disease · Sep 11, 2026Peer-reviewedCancer Biology

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma

Shikha Gupta, Prateek Khanna, Eddy Saad, Renée Maria Saliby, Shatha AbuHammad, Jiao Li, Bingchen Li, Prathyusha Konda, Usman Ali Ahmed, Ananthan Sadagopan, Qingru Xu, Ziad Bakouny, Wenxin Vincent Xu, Ramaprasad Srinivasan, Toni K. Choueiri, Srinivas R. Viswanathan

This study identifies CDK4/6 and mTORC1 pathway activation in tRCC and shows that their dual inhibition synergistically suppresses tRCC cell growth in vitro and xenografts in vivo.

bioRxiv · Jul 11, 2025 · PreprintCancer Biology

A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

Stephen Tang, Nebiyou Y. Metaferia, Marina F. Nogueira, Maya K. Gelbard, Sarah Abou Alaiwi, Ji-Heui Seo, Justin H. Hwang, Craig A. Strathdee, Sylvan C. Baca, Jiao Li, Shatha AbuHammad, Xiaoyang Zhang, John G. Doench, William C. Hahn, David Y. Takeda, , Srinivas R. Viswanathan

This study identifies PRMT1 as a critical regulator of AR signaling in prostate cancer through genome-scale CRISPR screening and shows its potential as a therapeutic target.

Cell Reports · Feb 1, 2022Peer-reviewedCancer Biology