Author

Ze-Yan Zhang

NYU Langone HealthORCID 0000-0002-7896-3013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Aram Sandaldjian ModrekiD· 2 shared Catherine DoiD· 2 shared Erik P. SulmaniD· 2 shared Giulia CovaiD· 2 shared Jane A. SkokiD· 2 shared Jerome M. KarpiD· 2 shared Ravesanker EzhilarasaniD· 2 shared Yingwen DingiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersGenomics

Aram Sandaldjian ModrekORCID

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2 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedAug 29, 2026

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

Aram Sandaldjian Modrek, Keerthivasan Raanin Chandradoss, Catherine Do…·Jane A. Skok

This study shows that DNA damage in glioblastoma cells leads to long-term chromatin changes and gene expression reprogramming, affecting cellular function and tumor outcomes.

DOI 10.1038/s41467-026-77331-4

humanDNA methylation

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BioinformaticsbioRxivPreprintMay 7, 2025

mtgRNA-db: An annotated database of multi-target CRISPR-Cas9 guide-RNAs in the human genome

Aram Sandaldjian Modrek, Khoi Huynh, Catherine Do…·Erik P. Sulman

The paper creates a database of multi-target CRISPR-Cas9 guide-RNAs with on- and off-target scores and provides a web tool for selecting these guide-RNAs.

1 citation

humanCRISPR screen

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