Aram Sandaldjian Modrek

This study shows that DNA damage in glioblastoma cells leads to long-term chromatin changes and gene expression reprogramming, affecting cellular function and tumor outcomes.

This study uses single-cell multiomic profiling to show radiation-induced transcriptional and chromatin remodeling in GBM, revealing dose-dependent and cluster-specific regulatory changes.

The paper creates a database of multi-target CRISPR-Cas9 guide-RNAs with on- and off-target scores and provides a web tool for selecting these guide-RNAs.

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.