Keerthivasan Raanin Chandradoss

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

This study shows that DNA damage in glioblastoma cells leads to long-term chromatin changes and gene expression reprogramming, affecting cellular function and tumor outcomes.

Learning induces persistent chromatin loops underlying robust gene expression during memory recall

The paper identifies persistent chromatin loops in hippocampal neurons after fear conditioning that correlate with gene expression changes during memory recall.

Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons

The paper shows that persistent chromatin loops in human neurons influence gene expression plasticity during and after stimulation, with some loops maintaining repression or activation for up to five days.

MASTR-seq: Multiplexed Analysis of Short Tandem Repeats with sequencing

MASTR-seq enables cost-effective, high-throughput, and accurate measurement of STR length and DNA methylation at single-allele resolution using nanopore sequencing.

Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndrome

The paper shows that in fragile X syndrome, long-range heterochromatinization of distal synaptic genes with STR instability is reversible by overexpression of a pre-mutation-length CGG tract.

An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

The paper shows Swi6/HP1 binds siRNA-DNA hybrids at dg-dh repeats to initiate heterochromatin formation independently of H3-K9 methylation.

CTCF mediated genome architecture regulates the dosage of mitotically stable mono-allelic expression of autosomal genes

The paper shows that CTCF-mediated chromatin loops create genomic insulation that enables mono-allelic expression of autosomal genes and protects their dosage from fluctuations.

Repurposing the biased visibility in HiC datasets to mark dynamically regulated condensed and decondensed chromatin states genome-wide.

The paper shows HiC datasets have bias due to chromatin condensation, which can be used to study dynamic chromatin states.

Did position-effect guide the evolutionary dynamics of developmental gene expression?

The paper examines how loss of synteny between genes and conserved noncoding elements (CNEs) impacts developmental gene expression in rodents, linking it to evolutionary changes in brain development.