Thaddeus G. Golos

Ferumoxytol dynamic contrast-enhanced MRI for in vivo longitudinal cotyledon perfusion assessment with pathology correlation in a rhesus macaque thrombotic injury model

This paper uses ferumoxytol DCE-MRI to track placental cotyledon perfusion in rhesus macaques and correlates it with thrombotic injury pathology across gestation.

Bridging Cotyledon Pathology and Perfusion in Healthy Primate Pregnancy

The paper quantifies placental pathology and maternal perfusion in healthy primate pregnancies, revealing associations between stromal mineralization and reduced perfusion, and identifying key pathologies linked to vascular malperfusion.

Temporally resolved early BMP-driven transcriptional cascade during human amnion specification

This study establishes a temporally resolved BMP-dependent transcriptional cascade during human amnion specification using a stem cell model and identifies TFAP2A as a critical regulator.

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

Temporally resolved single cell transcriptomics in a human model of amniogenesis

The paper uses single-cell transcriptomics to study amniogenesis in human and primate models, identifying a new CLDN10+ amnion progenitor state and its role in amnion fate.

Derivation of macaque trophoblast stem cells

The paper develops macaque trophoblast stem cells (TSCs) as an in vitro model for studying primate placentation, showing their ability to differentiate into syncytiotrophoblasts and express trophoblast markers.

Haplotype-phased common marmoset embryonic stem cells for genome editing using CRISPR/Cas9

This study provides haplotype-resolved genome characterization of a marmoset ESC line and demonstrates CRISPR/Cas9 targeting and neuronal differentiation capabilities.