Sridhar Rao

This study maps the molecular landscape of hypertension using single-cell data from multiple organs and models, linking genetic variants to disease mechanisms.

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

This paper develops a machine learning model to identify molecularly distinct DDR subgroups in prostate cancer, revealing concurrent repair deficiencies and improving therapeutic stratification.

The paper maps chromatin interactions in human arterioles, linking genetic variants to gene expression and hypertension mechanisms.

The paper investigates the physiological role and mechanisms of a noncoding haplotype associated with blood pressure by combining animal models, genome editing, and chromatin analysis.

The paper maps epigenetic and genetic regulation in human endothelial and vascular smooth muscle cells, showing strong correlations between gene expression and chromatin features, and demonstrates SNP effects on gene expression through chromatin loops.

This study establishes a temporally resolved BMP-dependent transcriptional cascade during human amnion specification using a stem cell model and identifies TFAP2A as a critical regulator.

This study shows GATA4 regulates epithelial morphogenesis in the mouse stomach, determining whether cells become columnar or squamous epithelium.

This study shows FoxO1 is essential for human definitive endoderm formation by regulating gene expression during hepatocyte differentiation.