HIV-1 Envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane
Adriana Quijada‐Freire, César A. Santiago, Eva M. García‐Cuesta, Blanca Soler Palacios, Rosa Ayala-Bueno, Sofía R. Gardeta, Enara San Sebastian, Eva Armendariz-Burgoa, Maria Carmen Puertas, Ricardo Villares, Urtzi Garaigorta, Luis Ignacio González‐Granado, José Miguel Rodrı́guez-Frade, Jakub Chojnacki, Javier Martínez‐Picado, Mario Mellado
This study shows that HIV-1 Env proteins induce CXCR4 clustering on T cells, which is linked to infection, and highlights the importance of co-receptor spatial organization in viral entry.
bioRxiv · Jun 11, 2025Immunology