Javier Martínez‐Picado

Human CD34⁺ progenitor-derived DC2 and DC3 subsets support CD169-mediated HIV-1 uptake

This study identifies DC2 and DC3 subsets as key contributors to CD169-mediated HIV-1 capture and dissemination through MEND-driven internalization into sac-like compartments.

Humanized FLT3 mice display enhanced tissue engraftment and support HIV-1 persistence and rebound

This study introduces a novel humanized FLT3 mouse model that supports enhanced development of human innate immune cells and HIV-1 persistence, mimicking human viral reservoirs.

Pediatric Long COVID Is Characterized by Myeloid CCR6 Suppression and Immune Dysregulation

This study identifies immune dysregulation and myeloid CCR6 suppression in pediatric long COVID, with CCR6 expression distinguishing long COVID from controls.

MIF overexpression upon SARS-CoV-2 infection induces neural regeneration in human-derived brain organoids

This study shows that MIF overexpression after SARS-CoV-2 infection promotes neural regeneration in human brain organoids through EGFR signaling and self-upregulation.

HIV-1 Envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

This study shows that HIV-1 Env proteins induce CXCR4 clustering on T cells, which is linked to infection, and highlights the importance of co-receptor spatial organization in viral entry.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.