Author

César A. Santiago

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-5149-1722Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adriana Quijada‐FreireiD· 1 shared Álvaro Martínez‐del‐PozoiD· 1 shared Blanca Soler PalaciosiD· 1 shared Diego CarleroiD· 1 shared Diego Heras‐MárqueziD· 1 shared Enara San Sebastian· 1 shared Ernesto Arias‐PalomoiD· 1 shared Esperanza Rivera‐de‐TorreiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Adriana Quijada‐FreireORCID

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2 papers

Recent·Most cited

The action mechanism of actinoporins revealed through the structure of pore-forming intermediates

Rocío Arranz, César A. Santiago, Simonas Masiulis, Esperanza Rivera‐de‐Torre, Juan Palacios‐Ortega, Diego Carlero, Diego Heras‐Márquez, José G. Gavilanes, Ernesto Arias‐Palomo, Álvaro Martínez‐del‐Pozo, Sara García‐Linares, Jaime Martín‐Benito

The paper determines the structures of two actinoporins in a membrane environment using cryogenic electron microscopy, revealing their pore-forming mechanism through intermediate states.

Science Advances · Sep 24, 2025Peer-reviewedBiochemistry

HIV-1 Envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

Adriana Quijada‐Freire, César A. Santiago, Eva M. García‐Cuesta, Blanca Soler Palacios, Rosa Ayala-Bueno, Sofía R. Gardeta, Enara San Sebastian, Eva Armendariz-Burgoa, Maria Carmen Puertas, Ricardo Villares, Urtzi Garaigorta, Luis Ignacio González‐Granado, José Miguel Rodrı́guez-Frade, Jakub Chojnacki, Javier Martínez‐Picado, Mario Mellado

This study shows that HIV-1 Env proteins induce CXCR4 clustering on T cells, which is linked to infection, and highlights the importance of co-receptor spatial organization in viral entry.

bioRxiv · Jun 11, 2025Immunology