Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism
Jake E. Doiron, Mahmoud H. Elbatreek, Huijing Xia, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Ian H. Driver, Naoto Muraoka, Martin Borch Jensen, Smitha Shambhu, W.H. Wilson Tang, Kyle Brian LaPenna, Thomas E. Sharp, Traci T. Goodchild, , David J. Lefer
This study shows H2S deficiency in HFpEF patients and models, and that H2S supplementation or combination with GLP-1/glucagon agonists improves HFpEF outcomes.
JACC Basic to Translational Science · Aug 6, 2025Peer-reviewedPharmacology & Toxicology