Author

Smitha Shambhu

University of Central Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Martin Borch JenseniD· 3 shared Dimitry Popov· 2 shared Hikaru Miyazaki· 2 shared Ian H. DriveriD· 2 shared Jingshu CheniD· 2 shared Vishwaraj SontakeiD· 2 shared Adam H. BiedrzyckiiD· 1 shared Aleksandra TataiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Martin Borch JensenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Multispecies, Modality-Agnostic Scalable In Vivo Mosaic Screening Platform for Therapeutic Target Discovery

Vishwaraj Sontake, Vinay K. Kartha, Neety Sahu, Daniel Fuentes, Linda Chio, Hikaru Miyazaki, Jingshu Chen, Arnav Gupta, Jesi Nonora, Arthi Vaidyanathan, Smitha Shambhu, Gayathri Donepudi, Carmen Le, Lianna Fung, Amber Lim, , Martin Borch Jensen

The paper presents an in vivo screening platform for validating therapeutic targets across species and modalities, identifying functional targets in fibrosis and osteoarthritis models.

bioRxiv · Mar 4, 2026 · PreprintGenomics

Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis

Shuang Wu, Ian Driver, Meihui Luo, Hikaru Miyazaki, Smitha Shambhu, Dimitry Popov, Liyuan Yang, Jing Wang, Jia Ma, Junfeng Guo, Jarron Atha, Aleksandra Tata, Eric A. Hoffman, Yujiong Wang, Purushothama Rao Tata, , Xiaoming Liu

This study shows that a bleomycin-induced lung injury model in ferrets shares key pathophysiological, cellular, and molecular features with human idiopathic pulmonary fibrosis, suggesting its use for IPF research.

npj Regenerative Medicine · Nov 21, 2025Peer-reviewedPathology

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism

Jake E. Doiron, Mahmoud H. Elbatreek, Huijing Xia, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Ian H. Driver, Naoto Muraoka, Martin Borch Jensen, Smitha Shambhu, W.H. Wilson Tang, Kyle Brian LaPenna, Thomas E. Sharp, Traci T. Goodchild, , David J. Lefer

This study shows H2S deficiency in HFpEF patients and models, and that H2S supplementation or combination with GLP-1/glucagon agonists improves HFpEF outcomes.

JACC Basic to Translational Science · Aug 6, 2025Peer-reviewedPharmacology & Toxicology

Variation in transformation frequency and competence gene expression among serotype 3 Streptococcus pneumoniae

Smitha Shambhu, Eleonora Cella, Taj Azarian

This study examines variation in transformation frequency and competence gene expression among serotype 3 Streptococcus pneumoniae strains, finding correlations with gene expression differences and promoter sequence variation.

bioRxiv · Aug 19, 2024 · PreprintMicrobiology