Structural promiscuity in the human circulatory IgA1 clonal repertoire
Amber D. Rolland, Sofia Kalaidopoulou Nteak, Gestur Vidarsson, Albert Bondt, Albert J. R. Heck
The paper identifies structurally promiscuous IgA1 clones in human serum that exist as both monomers and J-chain-coupled dimers, challenging the view that these forms are clonally distinct.
Proceedings of the National Academy of Sciences · May 6, 2026Peer-reviewedBiochemistry