FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania F. Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, , Yoshitaka Nagai
This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.
eLife · Feb 13, 2023Peer-reviewedNeuroscience