Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis
Yi Xiao, Diana D. Shi, Lei Guo, Ethan Neumann, Michael M. Levitt, Pranita Kaphle, Tracey E. Shipman, Haocheng Li, Feng Cai, Denise M. O. Ramirez, Lauren G. Zacharias, Zhenkang Chen, Mathew Lin, Vineshkumar Thidil Puliyappadamba, Tao Chen, , Samuel K. McBrayer
This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.
bioRxiv · Aug 12, 2025 · PreprintCancer Biology