Lizhe Zhuang

The paper generates organoid models of Barrett oesophagus and oesophageal adenocarcinoma to study disease progression and therapy response.

Songbird is a single cell whole genome sequencing copy number caller that detects whole genome duplication and outperforms existing tools in breakpoints identification and true copy number detection.

This study uses spatial transcriptomic and proteomic profiling to identify cell interaction patterns that predict progression of Barrett's esophagus.

This study uses multiplexed imaging to analyze immune and stromal cell changes in abdominal aortic aneurysms (AAAs) based on C-reactive protein (CRP) levels, revealing distinct immune cell distributions and macrophage phenotypes associated with CRP deposition.

The paper introduces a dual-modality imaging method combining high-resolution immunofluorescence and imaging mass cytometry to generate whole-slide IMC images with accurate single-cell segmentation.