Helen Eachus

Lifelong molecular consequences of high Glucocorticoids exposure during development

This study investigates the lifelong molecular effects of high glucocorticoid exposure during development using a zebrafish model, identifying GC-primed genes and epigenetic changes linked to psychiatric disorder risk factors.

Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish

This study shows that elevated glucocorticoid exposure during zebrafish development disrupts hypothalamic neurogenesis, leading to developmental abnormalities and reduced survival.

Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish.

This study uses optogenetics to chronically activate glucocorticoid signaling in larval zebrafish, showing impaired stress response and reduced POMC-expressing cells.

Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish

This study identifies two distinct GR-regulated transcription pathways in zebrafish brains, showing synaptic activity's role in GR-mediated transcription of aplp1.