Author

Anna Tochwin

University of Exeter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Helen EachusiD· 2 shared Min‐Kyeung ChoiiD· 2 shared Soojin RyuiD· 2 shared Alex Cook· 1 shared Anna WalentinssoniD· 1 shared Charles R. TyleriD· 1 shared Erik MichaëlssoniD· 1 shared Johanna Kaspareit· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Helen EachusORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lifelong molecular consequences of high Glucocorticoids exposure during development

Min‐Kyeung Choi, Alex Cook, Kanak Mungikar, Helen Eachus, Anna Tochwin, Matthias Linke, Susanne Gerber, Soojin Ryu

This study investigates the lifelong molecular effects of high glucocorticoid exposure during development using a zebrafish model, identifying GC-primed genes and epigenetic changes linked to psychiatric disorder risk factors.

bioRxiv · Feb 13, 2023 · PreprintNeuroscience

Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish

Helen Eachus, Min‐Kyeung Choi, Anna Tochwin, Johanna Kaspareit, May Ho, Soojin Ryu

This study shows that elevated glucocorticoid exposure during zebrafish development disrupts hypothalamic neurogenesis, leading to developmental abnormalities and reduced survival.

bioRxiv · Jan 27, 2023 · PreprintNeuroscience

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

Matthew J. Winter, Yosuke Ono, Jonathan S. Ball, Anna Walentinsson, Erik Michaëlsson, Anna Tochwin, Steffen Scholpp, Charles R. Tyler, Steve Rees, Malcolm J. Hetheridge, Mohammad Bohlooly‐Y

The paper identifies three genes associated with heart failure using human exome sequencing and validates their roles in cardiovascular function using zebrafish CRISPR/Cas9 mutagenesis.

Frontiers in Pharmacology · Apr 25, 2022Peer-reviewedMolecular Biology