Richard Baines

The paper shows that different parts of the Drosophila larval locomotor network respond differently to heat stress during a critical period, leading to varied functional and structural changes.

This study investigates the influence of circadian rhythms on seizure severity in Drosophila, finding a sex-dependent effect and a bimodal recovery pattern.

The paper manipulates neuronal activity during an embryonic critical period in Drosophila and finds cell type-specific changes in intrinsic excitability that persist into larval development.

The paper shows that GABAergic signaling controls the timing of a critical period in Drosophila melanogaster's locomotor network, with agonists accelerating and antagonists delaying its opening.

This study identifies FAD binding by the C-terminus of Drosophila CRY as essential for magnetosensitivity, explaining non-canonical magnetosensitivity observations.

The paper identifies mitochondrial ROS and HIF-1α signaling as critical for critical period plasticity in Drosophila.

This study identifies a circadian mechanism controlling critical periods in Drosophila larval neuronal development, showing that light manipulation can alter these periods and induce seizures.

This study shows that balanced neural activity during a critical period is essential for normal circuit development, as imbalances lead to hyperexcitability and reduced network robustness.

This study identifies simvastatin and BMS-204352 as potential ASD therapies in a Drosophila Nf1 model by reducing tactile hypersensitivity and synaptic transmission defects.

This study shows that Puckered-mediated JNK signaling in pioneer neurons regulates VNC architecture and motor circuit coordination in Drosophila embryos.

This study identifies a novel anticonvulsant compound that targets neuronal homeostasis by increasing Pumilio expression, showing efficacy in Drosophila and mouse seizure models.

This study shows that loss of NF1 in Drosophila causes tactile hypersensitivity and synaptic transmission deficits, similar to ASD features, and these effects are rescued by knocking down Ras proteins.

The paper compares seizure-induction methods in Drosophila to identify the most effective for studying seizure-prone mutants.

The paper validates four Drosophila premotor interneuron driver lines using electrophysiology, confirming their monosynaptic connection to the aCC motoneuron.

This study identifies two distinct GR-regulated transcription pathways in zebrafish brains, showing synaptic activity's role in GR-mediated transcription of aplp1.

This study shows that Jeb-Alk signaling stabilizes motor circuit function during postembryonic growth in Drosophila by preventing excessive synaptic strengthening.

The paper shows that manipulating activity of a specific excitatory interneuron during a critical period in Drosophila larval development alters network tuning, with nitric oxide signaling playing a role dependent on prior network activity.

The paper develops a split-QF system for tunable transgene expression in Drosophila, compatible with existing split-GAL4 and split-LexA lines.

The paper identifies Mef-2 and p300 interaction as a regulatory mechanism for Pumilio expression in Drosophila in response to synaptic excitation.

This study investigates how mutations in Membrin/GOSR2 affect dendritic growth and synaptic integrity in Drosophila models, revealing their role in neurological disorders.