Matthias Linke

This study investigates how 16p11.2 copy number variations affect genome architecture and transcription during neurodevelopment, finding both local dosage effects and broader chromatin changes.

This study evaluates improvements in direct RNA sequencing (DRS) using RNA004 chemistry and modified-base-calling models, showing enhanced throughput, accuracy, and detection of RNA modifications in clinical applications.

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

This study investigates the lifelong molecular effects of high glucocorticoid exposure during development using a zebrafish model, identifying GC-primed genes and epigenetic changes linked to psychiatric disorder risk factors.

This study shows that early life stress alters the transcriptome of NG2+ glia, increases Nav channel activity, and impairs cognitive performance in adulthood.