Liang Sun

Pannexin-1 regulates cellular identity and excitability in the developing cortex

This study identifies de novo PANX1 mutations in individuals with PMG and microcephaly, showing they disrupt glycosylation, increase ATP release, and alter cortical development through ion conductance and cell fate regulation.

An autonomous LLM agent platform for computational binder design and conjugation-aware prioritization of antibody drug conjugates

This paper introduces an autonomous LLM agent platform for computational binder design and ADC prioritization, achieving accurate classification across oncology targets with minimal human intervention.

Development of the Early Childhood Duodenum across Ancestry, Geography and Environment

The paper creates a cellular and spatial map of the duodenum in children, revealing environmental and developmental influences on intestinal cell states.

Metabolic pathway competition sensitizes thioredoxin reductase-depleted Candida albicans to cell wall stress and antifungals

This study shows that Trr1 depletion in C. albicans increases sensitivity to antifungals and cell wall stress by disrupting metabolic pathways and cell wall synthesis.

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

This study compares neuronal activity and gene expression in CDD patient-derived neurons from two differentiation methods, finding early hyperexcitability in organoid-derived neurons but not induced neurons.

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

This study shows that enteric glia regulate Paneth cell secretion and microbial ecology but have minimal effects on overall intestinal epithelial transcription.

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs

This study compares single-cell transcriptomic profiles of human inner ear organoids with fetal and adult inner ear tissues to assess their ability to model inner ear disorders.

RNA-seq: primary cells, cell lines and heat stress

The paper uses RNA-seq to analyze gene expression in chicken and human cells under heat stress conditions to identify differentially expressed genes.