Jeffrey A. Lewis

The paper identifies dynamic acetylation changes in yeast during heat shock, showing acetylation regulates protein activity to enhance the heat shock response.

The paper shows that Hog1 in wild S. cerevisiae strains has a broader stress response than in lab strains, with distinct non-osmotic stress gene regulation.

The paper introduces MIC*, a framework that translates ordinal viability data into biologically interpretable units, improving analysis of microbial survival assays.

The paper develops plasmids for CRISPR-Cas9 genome editing in yeast using retron-mediated amplification of repair templates, achieving high editing efficiencies.

The paper examines how diet affects host tolerance to a bacterial pathogen in birds, finding that protein-fed birds show greater transcriptional priming and tolerance during recovery.

The paper compares the hyposaline stress responses of two diatoms to understand the genetic basis of salinity adaptation and freshwater colonization.

This study identifies molecular mechanisms underlying stress resistance in yeast by analyzing natural genetic variation and cross protection responses to different stressors.

This study uses time-resolved transcriptomics to analyze the dynamic gene expression response of a euryhaline diatom to acute hypoosmotic stress and reveals distinct stages of freshwater acclimation.

The paper sequenced the genome of a nonphotosynthetic diatom to understand metabolic changes after losing photosynthesis and found key genetic constraints and alternative pathways for energy acquisition.

This study compares RNA isolation methods and finds phenol extraction preferentially isolates membrane-associated mRNAs, causing spurious differential expression signals in RNA-seq analyses across batches.

The paper quantifies the dynamic heat shock proteome in budding yeast using TMT-MS3, revealing differential protein expression and PTM regulation over time.

The paper links gene expression variation to a stress defense trait in yeast by identifying a QTL hotspot locus affecting ethanol-induced cross protection.