Wei Li

This study shows that GCK-MODY has diet- and duration-dependent effects on lipid profiles and kidney disease in mice, revealing long-term complications previously unrecognized.

This study identifies DNAH14 as critical for sperm motility by reducing flagellar beat amplitude, and suggests a potential therapeutic approach through increased sperm concentration in IVF.

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

This study identifies the dynamic roles of non-A residues in poly(A) tails during mouse oocyte-to-embryo transition, showing their impact on mRNA stability and degradation.

This study compares poly(A) tail dynamics during oocyte-to-embryo transition across four mammalian species, identifying conserved and divergent features of maternal mRNA regulation.

The paper shows that sperm cooperation in mice forms clusters at the utero-tubal junction, facilitating oviduct entry and fertilization, with defects in this process linked to infertility.

This study shows that Mettl3 and m6A modification influence liver metabolic disorders and insulin resistance in mice fed a high-fat diet.

This paper develops a CRISPR-based diagnostic platform for SARS-CoV-2 detection with a low detection limit and no cross-reactivity.

The paper investigates the temporal roles of paternal imprinted loci H19-DMR and IG-DMR in prenatal embryonic development using semi-cloned embryos.