Alejandro J. Vila

Pseudomonas aeruginosa evolves to an infection state of reduced virulence and enhanced survival during antibiotic selection in an airway tissue model

This study shows that antibiotic selection in a human airway tissue model of Pseudomonas aeruginosa leads to evolution of less virulent, tissue-preserving infections with enhanced survival.

Adaptive landscape of the metallo-β-lactamase NDM to emerging β-lactam-based therapies

This study explores how NDM-1 evolves under different therapeutic pressures to predict resistance to emerging β-lactam-based therapies.

Functional export of NDM-7 to outer membrane vesicles in Klebsiella pneumoniae compromises imipenem and cefiderocol activity

This study shows that NDM-7 carbapenemase is exported to outer membrane vesicles in Klebsiella pneumoniae, enabling extracellular antibiotic degradation and conferring resistance to imipenem and cefiderocol.

OXA beta-lactamases from Acinetobacter spp. are membrane-bound and secreted into outer membrane vesicles

This paper identifies membrane-bound OXA beta-lactamases in Acinetobacter spp. and shows they are secreted into outer membrane vesicles, contributing to antimicrobial resistance.

Specific protein-membrane interactions promote the export of metallo-β-lactamases via outer membrane vesicles

The paper shows that specific protein-membrane interactions enhance the export of metallo-β-lactamases into outer membrane vesicles in Gram-negative bacteria.