Author

Matthew Harris

University of CambridgeORCID 0000-0002-7918-5735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Graham LaddsiD· 2 shared Ho Yan YeungiD· 2 shared Abigail PearceiD· 1 shared Anna BenrickiD· 1 shared Anne ClarkiD· 1 shared Belén ChanclóniD· 1 shared Bernard ThorensiD· 1 shared CAROLINE A. MIRANDAiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

Graham LaddsORCID

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2 papers

Recent·Most cited

Increased RAMP3 expression enhances GLP-1 mediated Glucose Stimulated Insulin Secretion in a Manner Dependent on Ca2+ Mobilisation

Abigail Pearce, Poonam Kumari, Claudia M. Sisk, Matthew Harris, Ho Yan Yeung, Sabrina Winfield, Kathleen M. Caron, Graham Ladds

RAMP3 complexes with GLP-1R at the plasma membrane, shifts signalling toward Ca2+ mobilisation, and enhances insulin secretion in INS-1 832/3 cells; Ramp3 loss blunts GLP-1 responses in mice.

Journal of Biological Chemistry · Aug 19, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest

GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor

Claudia Guida, CAROLINE A. MIRANDA, Ingrid Wernstedt Asterholm, Davide Basco, Anna Benrick, Belén Chanclón, Margarita V. Chibalina, Matthew Harris, Joely A. Kellard, Laura J. McCulloch, Joana I. Real, Nils J. G. Rorsman, Ho Yan Yeung, Frank M. Reimann, Makoto Shigeto, , Reshma D. Ramracheya

This paper identifies that GLP-1(9-36) inhibits glucagon secretion via the glucagon receptor, while GLP-1(7-36) uses the GLP-1 receptor, revealing distinct mechanisms for glucagon suppression.

bioRxiv · Apr 2, 2020 · PreprintMolecular Biology