Author

Lars Eckmann

University of California San DiegoORCID 0000-0002-7987-8742Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alan SaghatelianiD· 1 shared Ali ShawkiiD· 1 shared Alina N. SantosiD· 1 shared Amir ZarrinpariD· 1 shared Amulya Lingaraju· 1 shared Ana Carolina Dantas MachadoiD· 1 shared Anand Saran· 1 shared Anica Sayoc-BecerraiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSynthetic Biology

Alan SaghatelianORCID

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2 papers

Recent·Most cited

Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses

Pritha Chatterjee, Marianne Rebecca Spalinger, Charly Acevedo, Alina N. Santos, Casey M. Gries, Salomon Manz, Vinicius Canale, Ali Shawki, Anica Sayoc-Becerra, Hillmin Lei, Meli’sa S. Crawford, Lars Eckmann, James Borneman, Declan F. McCole

This study shows that intestinal epithelial PTPN2 limits AIEC colonization by enhancing antimicrobial peptide expression and immune responses.

Gut Microbes · Sep 15, 2025Peer-reviewedImmunology

Intestinal Transgene Delivery with Native E. coli Chassis Allows Persistent Physiological Changes

Baylee J. Russell, Steven D. Brown, Nicole Siguenza, Irene Mai, Anand Saran, Amulya Lingaraju, Erica S. Maissy, Ana Carolina Dantas Machado, Antônio F. M. Pinto, Concepcion Sanchez, Leigh-Ana M. Rossitto, Yukiko Miyamoto, R. Alexander Richter, Samuel B. Ho, Lars Eckmann, , Amir Zarrinpar

This study uses native E. coli as chassis to deliver transgenes, inducing persistent physiological changes in conventionally-raised hosts.

Cell · Aug 1, 2022Peer-reviewedSynthetic Biology