H. Nayanga Thirimanne

The paper constructs a unified transcriptomic landscape of lung cancer using RNA-seq data from 1,824 tumors, identifying nine molecular clusters with distinct biological and clinical features.

The paper identifies PTEN loss as a driver of aggressive NF2 mutant meningiomas and validates a cross-species model for preclinical testing.

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

The paper shows that aggressive high-grade NF2 mutant meningiomas have reduced YAP1 activity due to increased VGLL4 and FAT3/4 expression, linked to higher recurrence risk.

This study identifies distinct functions of Drosophila p53 isoforms in germline genome integrity and oocyte quality control, showing p53A mediates apoptosis and p53B is involved in DNA break repair.