Philipp Sievers

Adenosylhomocysteinase drives epigenetic and metabolic reprogramming in ZFTA-RELA ependymoma

This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.

Neuronal precursor cell persistence in Ganglioglioma is associated with ECM remodeling and immune cell infiltration

This study uses spatial transcriptomics to identify transcriptional programs in gangliogliomas that link ECM remodeling, immune infiltration, and persistent neuronal precursor-like states to tumor biology.

PTEN deficiency linked to chromosome 10q loss leads to aggressive NF2mutant meningioma biology

The paper identifies PTEN loss as a driver of aggressive NF2 mutant meningiomas and validates a cross-species model for preclinical testing.

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology

The paper constructs a transcriptomic landscape for medulloblastoma and ependymoma, revealing subtype-specific biology through clustering and molecular signatures.

Tumor-Associated Macrophages in Meningiomas: An Independent Prognostic Factor for Poor Survival Outperforming the Benefits of T cells

This study identifies high M2-TAM infiltration as an independent poor survival prognostic factor in meningiomas, overriding the beneficial effect of TILs.

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Aggressive high-grade NF2 mutant meningiomas downregulate oncogenic YAP signaling via the upregulation of VGLL4 and FAT3/4.

The paper shows that aggressive high-grade NF2 mutant meningiomas have reduced YAP1 activity due to increased VGLL4 and FAT3/4 expression, linked to higher recurrence risk.

Integrated phospho-proteogenomic and single-cell transcriptomic analysis of meningiomas establishes robust subtyping and reveals subtype-specific immune invasion

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

Distribution of GOPC:ROS1 and other ROS1 fusions in glioma types

The paper identifies ROS1 fusions in various glioma types through genomic and transcriptomic analysis, showing they are not restricted to specific subtypes.