Brian R. Calvi

The paper investigates how Drosophila tissues respond to unscheduled endocycling cells by activating a Src-JNK pathway, leading to a chronic wounding response that resembles wound healing but persists due to resistance to apoptosis.

The paper shows that unscheduled endocycling cells in Drosophila wing discs enter a reversible senescent-like arrest, impairing tissue growth despite promoting neighbor division.

The paper updates the Alliance of Genome Resources' central infrastructure, adding tools and enhancing data management and curation capabilities.

This study shows that the RNA-binding protein Swm is essential for maintaining intestinal progenitor cell identity and function in Drosophila.

This study identifies distinct functions of Drosophila p53 isoforms in germline genome integrity and oocyte quality control, showing p53A mediates apoptosis and p53B is involved in DNA break repair.

The paper identifies a Cyclin A - Myb-MuvB - Aurora B network that regulates the switch from mitotic to endoreplication cycles in Drosophila, showing its role in both developmental and induced endoreplication.