Alexander V. Mazin

BRCA1 promotes homologous recombination through separable DNA and RAD51 binding activities within its disordered region.

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

FBH1 and RAD54L directly interact and cooperate to drive replication fork reversal

This study identifies a direct physical and functional interaction between FBH1 and RAD54L, showing they cooperate to drive replication fork reversal.

RAD52 and RPA act in a concert promoting inverse RNA strand exchange

The paper investigates how RAD52 and RPA interact to promote inverse RNA strand exchange in DNA repair using NMR and biochemical methods.

Distinct roles of the two BRCA2 DNA binding domains in DNA damage repair and replication fork preservation

This study identifies distinct roles of BRCA2's two DNA binding domains in DNA repair and replication fork stability using genetic and biochemical methods.

Replication protein A binds RNA and promotes R-loop formation

This study shows RPA binds RNA and promotes R-loop formation, suggesting a role in RNA metabolism and genome maintenance.