Author

Paul Wan

AstraZeneca (United Kingdom)ORCID 0000-0002-8023-4557Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Abhishek SrivastavaiD· 1 shared David M. SmithiD· 1 shared E. L. RiversiD· 1 shared James D. RobinsoniD· 1 shared James L. TrevaskisiD· 1 shared Jon A. ReadiD· 1 shared JOSEFINE L. HANSENiD· 1 shared KARLY M. MATHERiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Abhishek SrivastavaORCID

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1 paper

Recent·Most cited

Direct β1/β2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis

KARLY M. MATHER, Michelle L. Boland, E. L. Rivers, Abhishek Srivastava, Marianne Schimpl, PAUL E. HEMSLEY, James D. Robinson, Paul Wan, JOSEFINE L. HANSEN, Jon A. Read, James L. Trevaskis, David M. Smith

This study evaluates BI9774, an AMPK activator, in a mouse model of NASH, finding it reduces liver steatosis but not fibrosis and causes cardiac side effects.

bioRxiv · May 30, 2024 · PreprintPharmacology & Toxicology