Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response
Christoph Hofmann, Adrian Serafin, Ole M. Schwerdt, Fereshteh Sadat Younesi, Florian Sicklinger, Ingmar Sören Meyer, Ellen Malovrh, Clara Sandmann, Lonny Jürgensen, Verena Kamuf‐Schenk, Claudia Stroh, Zoe Loewenthal, Mandy Rettel, Frank Stein, Hugo Albert Katus, , Mirko Völkers
This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.
bioRxiv · Jul 25, 2022 · PreprintMolecular Biology