Mandy Rettel

Granule microenvironment regulates the dual functions of FMR1

This study identifies FMR1 as a translational enhancer of oskar in Drosophila oocytes and reveals how its RNA-binding domains regulate opposing translation functions through phase separation.

Intrinsic flexibility of Type VII secretion central pore is required for substrate translocation

This study shows that the flexibility of the central pore in the ESX-5 type VII secretion system is essential for efficient substrate translocation, as rigidification of key residues impairs secretion.

Decoding translational control by cis-regulatory elements and RNA binding proteins in human effector T cells

The paper identifies RNA binding proteins and cis-regulatory elements that control translation in human effector T cells through multi-omics and machine learning analysis.

Muscle LIM Protein is a Non-Canonical RNA-Binding Protein that Engages in RNA-Dependent Cytoskeletal Assemblies

This study identifies MLP as a non-canonical RNA-binding protein in cardiomyocytes and shows its RNA-dependent interaction with cytoskeletal complexes.

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

Molecular dynamics of the matrisome across sea anemone life history

The paper identifies conserved matrisomal networks in sea anemones that coordinate life history transitions through proteomic and transcriptomic analysis.

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

This paper uses time-resolved multi-omics analysis of kidney fibrosis to identify novel mechanisms and validate transcription factors involved in collagen deposition.

A multi-year longitudinal harmonization of quality controls in mass spectrometry proteomics core facilities

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

Revealing the Arabidopsis AtGRP7 mRNA binding proteome by specific enhanced RNA interactome capture

The paper identifies proteins interacting with the AtGRP7 mRNA in Arabidopsis using enhanced RNA interactome capture, revealing ALBA proteins as binders.

Transverse Aortic COnstriction Multi-omics Analysis (TACOMA) uncovers pathophysiological cardiac molecular mechanisms

The paper presents TACOMA, a web tool integrating transcriptomics and proteomics data from a TAC-induced heart failure model, revealing molecular mechanisms of cardiac remodelling and failure.

The RNA-binding protein landscapes differ between mammalian organs and cultured cells

The paper characterizes RNA-binding protein landscapes in mouse organs using ex vivo eRIC, identifying over 1300 RBPs, many not previously found in cultured cells.

Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.

Structure and dynamics of the quaternary hunchback mRNA translation repression complex

The paper characterizes the quaternary hunchback mRNA repression complex formed by Brat, Pum, and Nanos, revealing its flexibility and independent binding of RNA components.

Aggregation and Disaggregation Features of the Human Proteome

The paper characterizes aggregation and disaggregation of proteins in human cells after heat shock, identifying factors influencing these processes and their implications for protein quality control.