Cancer BiologybioRxivPreprint
Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment
Binita Chakraborty, Prabuddha Chakraborty, Michael C. Brown…·Donald Patrick McDonnell
This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.
3 citations