Michael C. Brown

The paper identifies feature selectivity in M1 melanopsin photoreceptors for circadian regulation, showing their role in encoding light features that synchronize with the day-night cycle.

This paper demonstrates that attenuated virotherapy with PVSRIPO reprograms microglia to clear neurotoxic debris and enhance immune surveillance in mouse models.

This study identifies RELB as a key regulator that enhances TIL expansion and function, improving adoptive cell therapy for solid tumors.

The paper examines TIL expansion in glioblastoma by analyzing spatial organization and myeloid context, finding that TIL+ tumors have distinct immune interactions and vascular niches.

This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.

The paper uses CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function, finding BATF3 as a key gene that enhances memory T cell features and improves CAR T cell therapy outcomes.