José C. Reyes

The paper introduces a probabilistic framework to define chromatin accessibility in single-cell snATAC-seq data, avoiding arbitrary thresholds and providing a dynamic understanding of accessible regions.

This study identifies FGFR1 as a key driver of TMZ resistance in GBM through metabolic rewiring and cell cycle regulation, showing that FGFR1 inhibition restores TMZ sensitivity in preclinical models.

The paper shows that CHD8 recruitment to promoters depends on the ERK-ELK pathway and is essential for serum-dependent transcription of immediate early genes.

This study shows that human prefoldin affects co-transcriptional pre-mRNA splicing by modulating RNA polymerase II phosphorylation and splicing factor recruitment.