Sebastián Chávez

Mother cells can establish slow growing lineages in clonal populations since their earliest division cycles

The paper shows that young mother cells can establish slow-growing lineages in clonal yeast populations due to increased Whi5 expression linked to cell cycle phases.

Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle

The paper shows that transcription elongation control and mRNA stability coordinate to regulate gene expression strategies across the yeast cell cycle.

Growth rate regulates RNA polymerase II transcription elongation in Saccharomyces cerevisiae

The paper investigates how growth rate affects RNA polymerase II transcription elongation and RNA polymerase I association with chromatin in yeast under constant growth conditions.

The transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay

This study investigates how Sfp1 regulates mRNA synthesis and stability by interacting with Pol II and influencing mRNA fate through co-transcriptional binding.

The association of the RSC remodeler complex with chromatin depends on prefoldin-like Bud27 and determines nucleosome positioning and polyadenylation sites usage in Saccharomyces cerevisiae

This study shows that Bud27 is required for RSC chromatin association and proper nucleosome positioning, leading to altered polyadenylation site usage in yeast.

Gene regulation by synergism between mRNA decay and gene transcription

The paper models how RNA binding proteins can buffer or enhance gene expression by synergistically affecting transcription and mRNA decay rates, supported by analysis of yeast genomic datasets.

Human Prefoldin Modulates Co-transcriptional Pre-mRNA Splicing

This study shows that human prefoldin affects co-transcriptional pre-mRNA splicing by modulating RNA polymerase II phosphorylation and splicing factor recruitment.

Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast

The paper shows that cell volume regulates rDNA copy number and RNA polymerase I synthesis rate in yeast through a feedback mechanism involving Sir2.

The total mRNA concentration buffering system in yeast is global rather than gene-specific

The paper investigates mRNA buffering in yeast and finds that total mRNA concentration is buffered globally rather than gene-specifically.

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration

This study investigates how Xrn1 affects transcription elongation in yeast by analyzing RNA polymerase II profiles and chromatin structure.

Homeostasis in the Central Dogma of Molecular Biology: the importance of mRNA instability

The paper compares mRNA and protein homeostasis across organisms, finding mRNA ribostasis is less strict than proteostasis due to differences in synthesis cost and response capacity.