Stavros Trakoshis

The paper links mTOR-related synaptic pathology to functional hyperconnectivity in autism using mouse models and human fMRI data.

The paper shows that the Hurst exponent from fMRI BOLD signals indexes synaptic excitation-inhibition ratio, revealing sex-specific E:I imbalance in autistic mice medial prefrontal cortex.

The paper develops a phenotypic stratification model to predict autism subtypes based on SC-RRB balance and applies it to fMRI data, identifying subtype-specific neural circuitry and gene expression patterns.