Noemi Barsotti

Pre-Existing Serotonergic Pathways Guide the Navigation of Developing Serotonergic Axons

This study shows that developing serotonergic axons follow pre-existing serotonergic pathways, supporting the epiphytic guidance hypothesis.

Developmental excitation-inhibition imbalance permanently reprograms autism-relevant social brain circuits

This study shows that a transient developmental excitation-inhibition imbalance causes lasting social brain circuit dysfunction in mice, with behavioral and transcriptional consequences.

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome

This study investigates developmental dysconnectivity in 22q11.2 deletion syndrome using a cross-species approach, finding age-specific fMRI connectivity changes with synaptic origins.

Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels

This study shows that Ube3a gene overdosage causes sex-biased effects on brain connectivity, behavior, and gene expression in mice, linking it to autism-related phenotypes.

A cross-species link between mTOR-related synaptic pathology and functional hyperconnectivityin autism

The paper links mTOR-related synaptic pathology to functional hyperconnectivity in autism using mouse models and human fMRI data.

Deletion of autism risk gene Shank3 disrupts prefrontal connectivity

This study shows that deleting the autism risk gene Shank3 in mice disrupts prefrontal connectivity and is linked to social communication deficits.

Homozygous loss of autism-risk gene CNTNAP2 results in reduced local and long-range prefrontal functional connectivity

This study shows that homozygous loss of CNTNAP2 in mice reduces prefrontal and midline brain functional connectivity, linking it to autism-related traits.