An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Federica Capraro, Giancarlo Abis, Alessio Incocciati, Peter J. Simpson, Mehran Karimzadeh, Laura Masino, Alexander Barley, Tam T. T. Bui, Geoff P. Kelly, Hani Goodarzi, Maria R. Conte, Faraz K. Mardakheh
This study identifies an intrinsically disordered region in LARP6 that restricts conformational flexibility of the La-module, enabling RNA-binding selectivity and promoting cancer cell viability and invasion.
Nature Communications · Feb 19, 2026Peer-reviewedBiochemistry