Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy
Alyssa C. Indart, Huiyun Lyu, Vinh Q. Nguyen, Wendy L. Rosenthal, Jatin R. Palvai, Sophie S. Jang, Yue Chen, Kevin M. Jude, Leon Su, K. Christopher García, Jeffrey A. Bluestone, Qizhi Tang
This study develops a receptor-tethered orthogonal IL-2 system to enhance Treg persistence and efficacy in autoimmune diabetes, showing improved survival and therapeutic outcomes.
The Journal of Experimental Medicine · Jul 8, 2026Peer-reviewedImmunology