Author

Tatsuya Tsukahara

Harvard UniversityORCID 0000-0002-6928-8562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Sandeep Robert DattaiD· 4 shared David H. BranniD· 3 shared Bradley J. GoldsteiniD· 2 shared Hiroyuki TakedaiD· 2 shared Shinichi MorishitaiD· 2 shared Alexander FleischmanniD· 1 shared Alice Luo Clayton· 1 shared Allison D. OlivaiD· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersNeuroscience

Sandeep Robert DattaORCID

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6 papers

Recent·Most cited

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

David H. Brann, Tatsuya Tsukahara, Cyrus Tau, Dennis Kalloor, Rylin W. Lubash, Lakshanyaa Thamarai Kannan, Nell Klimpert, Mihály Köllő, Martín Escamilla-Del-Arenal, Bogdan Bintu, Andreas T. Schaefer, Alexander Fleischmann, Thomas C. Bozza, Sandeep Robert Datta

The paper shows that olfactory receptor expression in the nose follows a spatial code controlled by a retinoic acid gradient, aligning epithelial and brain maps.

Cell · Apr 29, 2026Peer-reviewedNeuroscience

Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

Brigitta B. Gundersen, William T. O’Brien, Melanie D. Schaffler, Maria N. Schultz, Tatsuya Tsukahara, Sandra Martín Lorenzo, Valérie Nalesso, Alice Luo Clayton, Ted G. Abel, Jacqueline N. Crawley, Sandeep Robert Datta, Yann Hérault

Experiments across four laboratories found that arbaclofen rescued cognitive deficits in mouse models of 16p11.2 deletion, without sedation or significant off-target behavioral effects.

bioRxiv · May 1, 2023 · PreprintNeuroscience

Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression

John B. Finlay, David H. Brann, Ralph N. Abi-Hachem, David Woojin Jang, Allison D. Oliva, Tiffany Ko, Rupali Gupta, Sebastian A. Wellford, E. Ashley Moseman, Sophie S. Jang, Carol H. Yan, Hiroaki Matusnami, Tatsuya Tsukahara, Sandeep Robert Datta, Bradley J. Goldstein

The paper investigates persistent smell loss after COVID-19 by analyzing olfactory epithelium inflammation and gene expression in patients with post-acute sequelae.

bioRxiv · Apr 17, 2022 · PreprintNeuroscience

CTCF looping is established during gastrulation in medaka embryos

Ryohei Nakamura, Yuichi Motai, Masahiko Kumagai, Candice L. Wike, Haruyo Nishiyama, Yoichiro Nakatani, Neva C. Durand, Kaori Kondo, Takashi Kondo, Tatsuya Tsukahara, Atsuko Shimada, Bradley Robert Cairns, Erez Lieberman Aiden, Shinichi Morishita, Hiroyuki Takeda

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

Genome Research · Jun 1, 2021Peer-reviewedGenomics

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

David H. Brann, Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca K. Chance, Iain C. Macaulay, Hsin-Jung Chou, Russell B. Fletcher, Diya Das, Kelly Street, Hector Roux de Bézieux, Yoon-Gi Choi, Davide Risso, , Sandeep Robert Datta

The paper identifies non-neuronal cell types in the olfactory system expressing SARS-CoV-2 entry genes, suggesting indirect mechanisms for COVID-19-associated anosmia.

Science Advances · Jul 24, 2020Peer-reviewedNeuroscience

Measuring the Landscape of CpG Methylation of Individual Repetitive Elements

Yuta Suzuki, Jonas Korlach, Stephen W. Turner, Tatsuya Tsukahara, Junko Taniguchi, Hideaki Yurino, Wei Qu, Jun Yoshimura, Yuji Takahashi, Jun Mitsui, Shoji Tsuji, Hiroyuki Takeda, Shinichi Morishita

The paper develops an algorithm to measure CpG methylation in repetitive elements using SMRT sequencing, achieving high sensitivity and precision in medaka and human genomes.

bioRxiv · Sep 14, 2015Genomics