Author
Harvard UniversityORCID 0000-0002-2647-0508Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Tsai‐Yu Lin, Giacomo Ceoldo, Kimberley D. House, M. Welty, Thao Thi Dang, Denise Klatt, Christian Brendel, Michael P. Murphy, Kenneth G. Cornetta, Danilo Pellin
MELISSA assesses insertional mutagenesis risk by analyzing integration site data, identifying over- and under-targeted genes and their impact on clone fitness.
Nature Communications · Aug 23, 2025Peer-reviewedBioinformatics
Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer
This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.
Cell stem cell · Dec 12, 2024Peer-reviewedGenetics
Jiecong Lin, My Anh Nguyen, Linda Yingqi Lin, Jing Zeng, Archana Verma, Nola R. Neri, Lucas Ferreira da Silva, Adele Mucci, Scot A. Wolfe, Kit L. Shaw, Kendell Clement, Christian Brendel, Luca Pinello, Danilo Pellin, Daniel E. Bauer
The paper develops ABSOLVE-seq to assess genome editing off-targets linked to genetic variants using primary cells and sequencing, enabling evaluation of human genetic diversity's impact on gene editing specificity.
bioRxiv · Jul 24, 2024 · PreprintGenomics
Danilo Pellin, Luca Biasco, Serena Scala, Clelia Di Serio, Ernst C. Wit
This paper develops a statistical model to infer hematopoietic stem cell dynamics in a gene therapy trial for Wiskott-Aldrich Syndrome and finds evidence for a myeloid-based developmental pathway.
The Annals of Applied Statistics · Sep 1, 2023Peer-reviewedBioinformatics
Luca Del Core, Danilo Pellin, Marco Andreas Grzegorczyk, Ernst C. Wit
This paper develops a stochastic framework to model cell differentiation networks from noisy clonal tracking data, providing tools for analyzing gene therapy studies.
bioRxiv · Jul 8, 2022 · PreprintSystems Biology
Jonathan Y. Hsu, Charles P. Fulco, Mitchel A. Cole, Matthew C. Canver, Danilo Pellin, Falak Sher, Rick Farouni, Kendell Clement, Jimmy A. Guo, Luca Biasco, Stuart H. Orkin, J Engreitz, Eric S. Lander, J. Keith Joung, Daniel E. Bauer, Luca Pinello
CRISPR-SURF deconvolves CRISPR tiling screen data to identify functional regulatory elements across CRISPR-Cas, CRISPRi, and CRISPRa experiments.
Nature Methods · Nov 20, 2018Peer-reviewedBioinformatics