Roberto F. Machado

This study shows that lipid droplet formation in pulmonary microvascular endothelial cells protects against hemin-induced inflammation and cell death.

This paper performs a local ancestry-aware GWAS on SCD cohorts to identify novel genetic loci associated with eGFR, uncovering regions linked to inflammation, ECM integrity, and other pathways relevant to SCD nephropathy.

This study shows that Nampt activates the mitochondrial unfolded protein response to enhance pulmonary arterial endothelial cell proliferation in PAH.

This study shows that pulmonary hypertension increases microglia and astrocyte density, reduces neuronal density, and causes TDP-43 mislocalization in both rat and human brain tissue.

This study shows that the Sphk1/S1P/S1P2 signaling axis promotes PASMC proliferation in PAH via activation of the mitochondrial unfolded protein response (UPRmt), which can be inhibited to reduce vascular remodeling.

The paper shows partial Wwox loss of function in mice worsens sepsis severity and neuroinflammation.

This study shows that knocking down WWOX in endothelial cells increases inflammation in ventilator-induced lung injury through zyxin upregulation and MAPK signaling changes.

This study shows that cigarette smoke and e-cigarette vapor reduce WWOX expression in lungs, leading to increased ARDS severity in mice.