Author

Carla J. Connelly

Johns Hopkins UniversityORCID 0000-0002-9218-5609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

Carol W. GreideriD· 4 shared Alexandra M. PikeiD· 2 shared Margaret A. StrongiD· 2 shared Rebecca KeeneriD· 2 shared Albert V. SmithiD· 1 shared Alex P. ReineriD· 1 shared Alexis J. BattleiD· 1 shared Allison E. Ashley‐KochiD· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMolecular Biology

Carol W. GreiderORCID

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4 papers

Recent·Most cited

Validation of human telomere length trans-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as novel human telomere length regulation genes

Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua S. Weinstock, Bohan Ni, Benjamin J. Strober, Stella W. Aslibekyan, Paul Livermore Auer, Lucas Barwick, Lewis C. Becker, John Blangero, Eugene R. Bleecker, Jennifer A. Brody, , Alexis J. Battle

The paper validates novel telomere length regulation genes POP5 and KBTBD6 identified through trans-ancestry GWAS using functional experiments in blood cells.

bioRxiv · Jul 12, 2023 · PreprintGenetics

Tel1 activation by the MRX complex is sufficient for telomere length regulation but not for the DNA damage response in S. cerevisiae

Rebecca Keener, Carla J. Connelly, Carol W. Greider

The paper shows that Tel1 activation by the MRX complex regulates telomere length but not the DNA damage response in S. cerevisiae, challenging existing models.

Genetics · Oct 24, 2019Peer-reviewedMolecular Biology

TIN2 functions with TPP1/POT1 to stimulate telomerase processivity

Alexandra M. Pike, Margaret A. Strong, John Paul T. Ouyang, Carla J. Connelly, Carol W. Greider

This study identifies a new TIN2 isoform, TIN2M, and shows that all TIN2 isoforms enhance telomerase processivity beyond TPP1/POT1, suggesting TIN2 is a functional component of the TPP1/POT1 complex.

Molecular and Cellular Biology · Aug 5, 2019Peer-reviewedMolecular Biology

BRD4 inhibitors block telomere elongation

Steven Wang, Alexandra M. Pike, Stella S. Lee, Margaret A. Strong, Carla J. Connelly, Carol W. Greider

This study identifies BRD4 as a telomere length regulator and shows that BRD4 inhibitors block telomere elongation in mouse and human cells.

Nucleic Acids Research · Jun 22, 2017Peer-reviewedMolecular Biology