Author

Pengyu Fu

Tianjin Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Heng ZhangiD· 2 shared Hang YiniD· 1 shared Hongtao ZhuiD· 1 shared Jie HaniD· 1 shared Lin WangiD· 1 shared Lingling ZhangiD· 1 shared Qian ZhangiD· 1 shared Shuai CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Heng ZhangORCID

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2 papers

Recent·Most cited

Defense-associated reverse transcriptases synthesize DNA in a telomerase-like manner

Heng Zhang, Shuai Chen, Shuqin Zhang, Youjing Zhang, Pengyu Fu, Tongyu Mao, Yancheng Zhan, Jie Han, Zhikun Liu, Zhengda Shan, Zhiyong Yuan, Ying Yu, Hang Yin

This study characterizes the reverse transcription activity of DRT10 and reveals its unique 2:1 RT:ncRNA assembly and mechanism of cDNA synthesis.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

Nature Communications · Feb 4, 2025Peer-reviewedBiophysics