Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome
Alejandro Ezequiel Cristófalo, Arvind Sharma, María Laura Cerutti, Kedar Sharma, Roberto Melero, Romina Paola Pardo, Fernando Alberto Goldbaum, Mario Juan Borgnia, Vanesa Zylberman, Lisandro Horacio Otero
This paper presents cryo-EM structures of engineered Shiga toxin-based immunogens that stabilize pentamers and show interaction with neutralizing antibodies, supporting their use in a vaccine for STEC-HUS.
Protein Science · May 24, 2025Peer-reviewedImmunology