James Q. Zheng

Fascin in Dendritic Protrusions is Required for Synaptic Plasticity

This study shows fascin is present in dendritic spines and regulates synaptic plasticity, challenging previous assumptions about its role in neurons.

A Critical Role for the Fascin Family of Actin Bundling Proteins in Axon Development, Brain Wiring and Function

This study shows that fascin is essential for axon development, brain wiring, and function in both cultured neurons and Drosophila melanogaster.

Sexual Dimorphism in Age-Dependent Neurodegeneration After Mild Head Trauma in Drosophila: Unveiling the Adverse Impact of Female Reproductive Signaling

This study shows that mild head trauma in Drosophila leads to age-dependent neurodegeneration, with females being more affected due to reproductive signaling.

A novel enhancer-AAV approach selectively targeting dentate granule cells

The paper identifies and validates an enhancer-AAV for selectively targeting dentate granule cells in the hippocampus using RNAseq data.

Characterizing the role of Ca2+ fluxes in defining fast and slow components of spontaneous Ca2+ local transients in OPCs using computational modeling

The paper develops a computational model to analyze Ca2+ flux contributions to spontaneous Ca2+ local transients in OPCs, revealing their stochastic nature and flux dependencies.

Repetitive Mild Head Trauma Induces Activity-Mediated Lifelong Brain Deficits in a Novel Drosophila Model

This study shows that repetitive mild head trauma in Drosophila causes long-term brain deficits, worsened in females, and links increased neuronal activity to chronic degeneration.