Author

Geoffrey A. Vargish

National Institutes of HealthORCID 0000-0002-2873-6517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Organism:non-human primate· 3 Assay:electronic health records· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Chris J. McBainiD· 5 shared Kenneth A. PelkeyiD· 5 shared Alex C. Cummins· 4 shared Anya S. PlotnikovaiD· 4 shared Arya Mohanty· 4 shared Brenda Leyva GarciaiD· 4 shared Bruno B. AverbeckiD· 4 shared Elisabetta FurlanisiD· 4 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Chris J. McBainORCID

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5 papers

Recent·Most cited

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

June Hoan Kim, Anna Vlachos, Vivek Mahadevan, Adam Caccavano, Tue G. Banke, Oliver Crawley, Ana I. Navarro, Xiaoqing Q Yuan, Daniel T. Abebe, Steven Hunt, Geoffrey A. Vargish, Ramesh Chittajallu, Mark A. G. Eldridge, Reza Azadi, Alex C. Cummins, , Kenneth A. Pelkey

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

bioRxiv · Sep 24, 2025 · PreprintNeuroscience

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

Geoffrey A. Vargish, Haley Rice, Xiaoqing Q Yuan, Steven Hunt, Brendan E. Hines, Anya S. Plotnikova, Arya Mohanty, Elisabetta Furlanis, Yating Wang, Min Dai, Brenda Leyva Garcia, Alex C. Cummins, Mark A. G. Eldridge, Bruno B. Averbeck, Kareem A. Zaghloul, , Chris J. McBain

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

bioRxiv · Jul 9, 2025 · PreprintNeuroscience

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Thien Khai Tran, Josselyn Vergara, Ana Pereira, Bram L. Gorissen, Sara Wills, Anna Vlachos, Ariel Hairston, Deepanjali Dwivedi, Sarah Du, Justin McMahon, Shuhan Huang, Annunziato Morabito, , Yating Wang

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Neuron · May 1, 2025Peer-reviewedNeuroscience

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

Adam Caccavano, Anna Vlachos, Nadiya McLean, Sarah Kimmel, June Hoan Kim, Geoffrey A. Vargish, Vivek Mahadevan, Lauren T. Hewitt, Anthony M. Rossi, Ilona Spineux, Sherry Jingjing Wu, Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Yating Wang, , Chris J. McBain

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

bioRxiv · Jan 20, 2024Neuroscience

A novel enhancer-AAV approach selectively targeting dentate granule cells

Emmie R. Banks, Claire‐Anne Gutekunst, Geoffrey A. Vargish, Anna Eaton, Kenneth A. Pelkey, Chris J. McBain, James Q. Zheng, Viktor Janos Oláh, Matthew JM Rowan

The paper identifies and validates an enhancer-AAV for selectively targeting dentate granule cells in the hippocampus using RNAseq data.

bioRxiv · Feb 3, 2023 · PreprintNeuroscience