Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Annie M Goettemoeller, Emmie R. Banks, Prateek Kumar, Viktor Janos Oláh, Katharine E McCann, Kelly South, Christina C. Ramelow, Anna Eaton, Duc Minh Duong, Nicholas T. Seyfried, David Weinshenker, Srikant Rangaraju, Matthew JM Rowan
This study identifies entorhinal cortex PV interneuron vulnerability to hAPP as a driver of hyperexcitability and tau pathology in Alzheimer's Disease.
Nature Communications · Sep 10, 2024Peer-reviewedNeuroscience