Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
Dong Luo, Jing Zheng, Shuning Lv, Ren Sheng, Maorong Chen, Xi He, Xinjun Zhang
This study shows Wnt induces FZD5/8 endocytosis and degradation via ZNRF3/RNF43, with RSPO1 stabilizing FZD5/8 and DVL promoting ligand-independent endocytosis.
eLife · Oct 10, 2025Peer-reviewedCell Biology